Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.

Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed through a series of successive steps before becoming tumorigenic in nude mice. Cell fusion studies indicated that radiation-induced tumorigenic phenotype in BEP2D cells could be completely suppressed by fusion with non-tumorigenic BEP2D cells. The differential expressions of known genes between tumorigenic bronchial and breast cells induced by alpha particles and their respective control cultures were compared using cDNA expression array. Among the 11 genes identified to be differentially expressed in BEP2D cells, three (DCC, DNA-PK and p21(CIP1)) were shown to be consistently down-regulated by 2 to 4 fold in all the 5 tumor cell lines examined. In contrast, their expressions in the fusion cell lines were comparable to control BEP2D cells. Similarly, expression levels of a series of genes were found to be altered in a step-wise manner among tumorigenic MCF-10F cells. The results are highly suggestive that functional alterations of these genes may be causally related to the carcinogenic process.     

高燃速丁羟推进剂配方研究

通过多种途径的试验,对高燃速丁羟推进剂配方进行了研究.试验结果表明,采用超细防结块氧化剂和液固组合燃速催化剂能使推进剂的燃速达到70mm/s以上(在6.864Mpa压强下);采用组合工艺助剂可改善推进剂工艺性能.本推进剂燃烧稳定,压强指数和温度敏感系数较低,力学性能良好,为高燃速推进剂的研制奠定了良好的基础.     

综合运用"四个机制"促进航空装备研制

根据航空武器装备研制应当建立竞争、评价、监督、激励“四个机制“的规定,结合本企业实际,就综合运用“四个机制“、促进航空装备研制提出了见解与建议.     

激光外差干涉仪光电信号处理方法及特点

叙述和分析了外差激光干涉光电信号处理主其特点，指出了它们各自的应用范围，同时介绍了一处新型的光电信号处理方法，它不仅使外差干涉仪用于动态测量，而且可以同时实现高分辩率测量 。     

复杂系统的可靠性分析方法研究

本文对未来的运载器的复杂控制系统的可靠性建模、分配和预计的一般方法和程序及综合分析方法进行了讨论和研究。并简述了复杂系统的计算机辅助可靠性分析。     

改进的次时间最优控制

本文在[1][2]基础上进一步探讨了次时间最优控制的改进问题,深入地阐明了次时间最优控制的某些特性后,提出了一个新的改进的设计方法。按照这种方法设计控制系统,不但实用而且可以大幅度提高次时间最优控制的最优性。并用实例比较了各种方法,证明了本文提出的方法的优越性。本文提出的方法应用于工程设计,对于提高系统的最优性是非常有效的。     

Implementation of a three-phase high-power-factor rectifier with NPC topology

A three-phase four-wire power factor corrector based on neutral-point-clamped (NPC) topology is adopted to reduce the current harmonics and increase the input power factor. Using the NPC topology, the voltage stress of power switches can be reduced to the half of the dc-link voltage. With the dc-link voltage controller and the phase locked loop circuit, the balanced and sinusoidal line currents can be drawn from the ac supply system under the balance and unbalance mains voltages. The hysteresis current comparators are adopted in the current control loop to track the line current commands. Three voltage levels are generated on the ac terminal to the neutral point. Simulations and experiments are provided to verify the validity and the effectiveness of the proposed control scheme.     

航天遥感仪器的反射镜轻量化的研究

反射镜轻量化是航天遥感仪器轻型化的重要技术途径之一。阐述了反射镜轻量化的意义,反射镜材料的选择,玻璃反射镜轻量化的结构型式和设计要求、设计方案和计算以及温度试验结果。     

基于仿真的单元化制造系统的单元分组

在传统单元分组方法的基础上,提出了用仿真方法解决瓶颈机床的分组问题.采用着色Petri网,对生产系统建模.以BEA算法作为分组基础,经过仿真试验得到最终的单元分组结果.试验表明,用仿真的方法能够弥补传统分组算法复杂的缺点.